Clinical Trials & Drug Policy: HHS/ARPA-H unveiled SURPASS, a faster, lower-cost clinical trials program designed to use shared infrastructure and real-time analysis to speed drug development. 340B Overhaul: HRSA approved 10 drug companies for the 340B Rebate Model Pilot Program starting Jan. 1, 2027, drawing renewed pushback from the AHA over added burdens for hospitals. Hospital Safety: AHA released an issue brief on evidence-based de-escalation strategies to reduce violence and improve safety for patients and staff. Mental Health & Care Access: WHO removed Uganda from its severe health-worker shortage recruitment restriction list, a move that could reshape nurse and midwife mobility. Health Tech & Care Delivery: South County Health joined Mayo Clinic’s Care Network while Minnesota lawmakers weigh merger impacts after a state economist warned hospital mergers can raise patient costs. Biotech & Manufacturing: Japan seeks to preserve domestic vaccine production capacity for future outbreaks and plans online foreign-investment filings; Nigeria extended its local pharma manufacturing executive order to 2029. New Research: A study linked low vitamin D to higher oxidative stress damage in heart tissue, and another reported appendectomy may lower later colorectal cancer risk. Business Moves: Digbi Health expanded precision biology to HRT care, and Nelipak invested in workforce skills at its Derry plant.